Molecular engineering of polymersome surface topology
نویسندگان
چکیده
منابع مشابه
Molecular engineering of polymersome surface topology.
Biological systems exploit self-assembly to create complex structures whose arrangements are finely controlled from the molecular to mesoscopic level. We report an example of using fully synthetic systems that mimic two levels of self-assembly. We show the formation of vesicles using amphiphilic copolymers whose chemical nature is chosen to control both membrane formation and membrane-confined ...
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Vesicles prepared in water from a series of diblock copolymers “polymersomes” are physically characterized and compared to lipid vesicles. With increasing molecular weight M̄n, the hydrophobic core thickness d for the self-assembled bilayers of poly(ethylene oxide)-polybutadiene (PEO-PBD) increases up to ≃20 nm considerably greater than any previously studied lipid system. The mechanical respons...
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Vesicles prepared in water from a series of diblock copolymers and termed “polymersomes” are physically characterized. With increasing molecular weight M̄n, the hydrophobic core thickness d for the self-assembled bilayers of polyethyleneoxide polybutadiene (PEO-PBD) increases up to ∼ 20 nm considerably greater than any previously studied lipid system. The mechanical responses of these membranes,...
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Generation of manifold mesh is an urgent issue in mathematical simulations of biomolecule using boundary element methods (BEM) or finite element method (FEM). Defects, such as not closed mesh, intersection of elements and missing of small structures, exist in surface meshes generated by most of the current meshing method. Usually the molecular surface meshes produced by existing methods need to...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2016
ISSN: 2375-2548
DOI: 10.1126/sciadv.1500948